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May
2002

It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous adiponectin secreted by adipocytes is post-translationally modified into eight different isoforms, as shown by two-dimensional gel electrophoresis.
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http://www.jbc.org/content/277/22/19521.full.pdf
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http://www.jbc.org/content/early/2002/03/23/jbc.M200601200.f
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http://www.jbc.org/cgi/doi/10.1074/jbc.M200601200
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