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Jun
2013

The development of disease concepts for conditions such as Alzheimer's disease (AD) is an ongoing social process that evolves over time. The biomedical paradigm about AD that has informed our culture's understanding of brain aging for the past several decades is currently undergoing a major and timely renovation in the early 21st century. This evolution is reflected in new guidelines issued by the National Institute on Aging and Alzheimer's Association (NIA/AA) for the diagnosis of AD and related conditions that aim at helping researchers identify and eventually treat AD in its presymptomatic stages.
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http://dx.doi.org/10.1093/geront/gns096DOI ListingPossible


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Jun
2012

Criteria for the clinical diagnosis of Alzheimer's disease (AD) were established in 1984, and they needed to be updated and revised, in vue of the scientific knowledge acquired over the last decades.
The National Institute on Aging (NIA) and the Alzheimer's Association (AA) sponsored a series of advisory round table meetings to establish a revision of diagnostic and research criteria for AD. The workgroups reviewed the biomarker, epidemiological, and neuropsychological evidence, and proposed conceptual frameworks as well as operational research criteria based on the prevailing scientific evidence to date.

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Mar
2016

In 2011, the National Institute on Aging and the Alzheimer's Association (NIA/AA) published new guidelines for the diagnosis of Alzheimer's disease (AD) twenty-seven years after old guidelines had been published. The working groups recognized the whole clinical trajectory of AD as consisting of three defined stages, namely, AD dementia, mild cognitive impairment due to AD and preclinical AD. In addition to some refinements of descriptions of clinical features, based on recent scientific evidences of biomarkers, biomarker evidence was incorporated into the diagnostic criteria for AD dementia and mild cognitive impairment(MCI) due to AD to enhance diagnostic accuracy in research settings.

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Nov
2012

In most research studies and clinical trials, Alzheimer disease (AD) has been diagnosed using the criteria developed by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association work group in 1984. Developments over the last 27 years have lead to the need for new diagnostic criteria.
Four articles in the journal Alzheimer's & Dementia in 2011 describe new criteria for AD dementia and mild cognitive impairment (MCI) due to the AD pathophysiological process (MCI due to AD) and the underlying rationale for them.

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Mar
2016

In 2011, the U.S. National Institute on Aging published guidelines for clinical diagnostics for Alzheimer's disease dementia.

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