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Apr
2017

Genome-wide association studies have struggled to identify functional genes and variants underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = 91) and used their tissue to generate induced pluripotent stem cells (iPSCs) and hepatocyte-like cells (HLCs) for genome-wide mapping of expression quantitative trait loci (eQTLs) and allele-specific expression (ASE). We identified many eQTL genes (eGenes) not observed in the comparably sized Genotype-Tissue Expression project's human liver cohort (n = 96).
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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(17)30088-7
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http://www.cell.com/cms/attachment/2089506281/2075403431/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S193459091730088
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