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Feb
2018

Several prediction models assessing future risk of exacerbations in adult patients with asthma have been published. Applicability of these models is uncertain because their predictive performance has often not been assessed beyond the population in which they were derived.
This study aimed to identify and critically appraise prediction models for asthma exacerbations and validate them in two clinically distinct populations.

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Feb
2018

The author describes a case of a non-osteoporotic adult presenting with multilevel compression fractures at the apex of the thoracic kyphosis after strenuous rope jumping. MRI demonstrated diffuse bone marrow changes in the vertebral bodies with only a very small unilateral endplate fracture. Besides highlighting the oftentimes neglected role of repetitive sub-pathological axial load forces in traumatic spinal injuries, the observed imaging pattern substantiates previous experimental studies which demonstrated that under cyclic axial loading the initial damage occurs in the cancellous regions of the bone (with observation of microscopic/50-100 μM long cracks), ultimately leading to a reduction in its elastic modulus.

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Feb
2018

Extreme congenital club foot deformities are common in developing countries, presenting at birth, persisting in children, adolescents and adults; as untreated/under-corrected by conservative and/or surgical means. Scores of confusing names exist in literature for such deformities with no good treatment available; mostly advocating unacceptable arthrodesis. The author researched this grey area for more than 40 years and successfully innovated improved surgical corrections, more acceptable to patients.

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Feb
2018

The original version of this Article incorrectly referenced the Figures in the Supplementary Information. References in the main Article to Supplementary Figure 7 through to Supplementary Figure 20 were previously incorrectly cited as Supplementary Figure 5 through to Supplementary Figure 18, respectively. This has now been corrected in both the PDF and HTML versions of the Article.

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Nov
2017

Despite the U.S. substantially outspending peer high income nations with almost 18% of GDP dedicated to health care, on any number of statistical measurements from life expectancy to birth rates to chronic disease,the U.

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Feb
2018

Macular Edema in Childhood Uveitis.

Klin Monbl Augenheilkd 2018 Feb 16. Epub 2018 Feb 16.
Justus G Garweg
Pediatric uveitis is associated with a high incidence of severe and frequently permanent visual loss. This article summarizes the current understanding of the disease and the therapeutic options that are available to improve treatment outcomes.
A Medline search spanning the last 10 years was undertaken using the key terms "pediatric uveitis" or "childhood uveitis" and "macular edema".

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Dec
1969

Accurate reporting on sex and gender in health research is integral to ensuring that health interventions are safe and effective. In Canada and internationally, governments, research organizations, journal editors, and health agencies have called for more inclusive research, provision of sex-disaggregated data, and the integration of sex and gender analysis throughout the research process. Sex and gender analysis is generally defined as an approach for considering how and why different subpopulations (e.

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Dec
1969

Although the peer review process is believed to ensure scientific rigor, enhance research quality, and improve manuscript clarity, many investigators are concerned that the process is too slow, too expensive, too unreliable, and too static. In this feasibility study, we sought to survey corresponding authors of recently published clinical research studies on the speed and efficiency of the publication process.
Web-based survey of corresponding authors of a 20% random sample of clinical research studies in MEDLINE-indexed journals with Ovid MEDLINE entry dates between December 1 and 15, 2016.

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Dec
1969

Knowledge development depends on an unbiased representation of the available evidence. Selective citation may distort this representation. Recently, some controversy emerged regarding the possible impact of swimming on childhood asthma, raising the question about the role of selective citation in this field.

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Dec
1969

Deciphering the amount of work provided by different co-authors of a scientific paper has been a recurrent problem in science. Despite the myriad of metrics available, the scientific community still largely relies on the position in the list of authors to evaluate contributions, a metric that attributes subjective and unfounded credit to co-authors. We propose an easy to apply, universally comparable and fair metric to measure and report co-authors contribution in the scientific literature.

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Dec
1969

There is evidence that direct journal endorsement of reporting guidelines can lead to important improvements in the quality and reliability of the published research. However, over the last 20 years, there has been a proliferation of reporting guidelines for different study designs, making it impractical for a journal to explicitly endorse them all. The objective of this study was to investigate whether a decision tree tool made available during the submission process facilitates author identification of the relevant reporting guideline.

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Dec
1969

Author reply.

Indian J Dermatol Venereol Leprol 2018 ;84(2):184-185
Supriya Kheur

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Jan
2018

Author accepted manuscript: Similarity and Decision Time in Preferential Choice.

Q J Exp Psychol (Hove) 2018 Jan 1:1747021818763054. Epub 2018 Jan 1.
Sudeep Bhatia, Timothy Mullett

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Feb
2018

Polarization in France.

Chirality 2018 Feb 16. Epub 2018 Feb 16.
Bart Kahr
The special relationship between France and the polarization of light from the beginning of the 19th century until the present day is reviewed in the lives and works of Étienne Louis Malus, François Arago, Jean-Baptiste Biot, Augustin Fresnel, Louis Pasteur, Frédéric Wallerant, Aimé Cotton, Francis Perrin, and Alain Aspect. To avoid a redundant presentation of information that can be found with an Internet search engine, the author emphasizes how the aforementioned individuals have influenced the studies of stereochemistry, molecular chirality, and the polarization of light in his research group.

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Feb
2018

Unfortunately, the original publication of this paper contains a mistake. The correct name of the 1st Author is Ming-Wei Wang.

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Feb
2018

The original version of this article unfortunately contained a mistake. Legends of Figures 1 and 2 were interchanged. The correct versions are given below.

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Feb
2018

Error in Author Degree and Surname.

JAMA 2018 Feb;319(6):617

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Feb
2018

Error in Author Listing.

JAMA Surg 2018 Feb 14. Epub 2018 Feb 14.

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Dec
1969

The purpose of this study is to describe the range and frequency of cutaneous lumbosacral and coccygeal findings encountered during the newborn examination in a population of apparently healthy babies, to determine if the prevalence of these findings is associated with race/ethnicity, and to report the frequency of co-occurrence of low-risk cutaneous findings.. Lumbosacral physical findings of 1121 infants were documented on well newborns at least 35 weeks or greater gestational age under the authors' care.

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Dec
1969

To the best of our knowledge, a strategic approach to define the contents of structured clinical documentation tools for both clinical routine patient care and research purposes has not been reported so far, although electronic health record will become more and more structured and detailed in the future.
To achieve an interdisciplinary consensus on a checklist to be considered for the preparation of disease- and situation-specific clinical documentation tools.
A 2-round Delphi consensus-based process was conducted both with 19 physicians of different disciplines and 14 students from Austria, Switzerland, and Germany.

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Feb
2018

Microfracture is a single-stage arthroscopic procedure used to treat small- and medium-sized cartilage defects, the clinical results of which have been mixed to date.
To retrospectively evaluate prospectively collected patient-reported outcomes (PROs) after microfracture as well as to determine patient-related and defect-related factors associated with clinical outcomes and which factors predict the need for additional surgery.
Case-control study; Level of evidence, 3.

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Dec
1969

The surgical treatment of proximal femoral fractures predominantly involves geriatric patients and is associated with high morbidity and mortality. However, analyses on postoperative infections or hematoma are rare.
Patients requiring surgical revision due to infection (n = 90) or hematoma (n = 77) in the postoperative phase were identified from an electronic database of 2000 consecutive patients surgically treated for proximal femoral fractures between 2006 and 2014.

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Dec
1969

Human rights in patient care and public health-a common ground.

Public Health Rev 2017 20;38:29. Epub 2017 Dec 20.
Maya Peled-Raz
Medical law and public health law have both served extensively as instruments of health protection and promotion-yet both are limited in their effect and scope and do not sufficiently cover nor supply a remedy to systematic, rather than anecdotal, mistreatments in the health care system. A possible solution to this deficiency may be found in the human rights in patient care legal approach. The concept of human rights in patient care is a reframing of international human rights law, as well as constitutional thought and tools, into a coherent approach aimed at the protection and furthering of both personal and communal health.

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Dec
1969

Forced sterilization of women as discrimination.

Public Health Rev 2017 14;38:15. Epub 2017 Jul 14.
Priti Patel
There has been a long history of subjecting marginalized women to forced and coerced sterilization. In recent years, the practice has been documented in countries in North and South America, Europe, Asia, and Africa. It has targeted women who are ethnic and racial minorities, women with disabilities, women living with HIV, and poor women.

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Dec
1969

The use of simulation-based education (SBE) in health professions, such as physical therapy, requires faculty to expand their teaching practice and development. The impact of this teaching on the individual faculty member, and how their teaching process changes or develops, is not fully understood. The purpose of this study was to explore individual physical therapist faculty members' experience with SBE and how those experiences may have transformed their teaching practice to answer the research questions: How do physical therapist faculty develop through including SBE and are there commonalities among educators?
An interpretive phenomenological analysis approach was used with a small sample of subjects who participated in three individual semi-structured interviews.

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Dec
1969

The dominant frameworks for describing how simulations support learning emphasize increasing access to structured practice and the provision of feedback which are commonly associated with skills-based simulations. By contrast, studies examining student participants' experiencesscenario-based simulations suggest that learning may also occur through participation. However, studies directly examining student participation during scenario-based simulations are limited.

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Dec
1969

Healthcare simulation has been widely adopted for health professional education at all stages of training and practice and across cognitive, procedural, communication and teamwork domains. Recent enthusiasm for in situ simulation-delivered in the real clinical environment-cites improved transfer of knowledge and skills into real-world practice, as well as opportunities to identify latent safety threats and other workplace-specific issues. However, describing simulation type according to place may not be helpful.

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Dec
1969

Prospects for Precision Medicine in Glomerulonephritis Treatment.

Can J Kidney Health Dis 2018 9;5:2054358117753617. Epub 2018 Feb 9.
Yulu Cherry Liu, Justin Chun
Glomerulonephritis (GN) consists of a group of kidney diseases that are categorized based on shared histopathological features. The current classifications for GN make it difficult to distinguish the individual variability in presentation, disease progression, and response to treatment. GN is a significant cause of end-stage renal disease (ESRD), and improved therapies are desperately needed because current immunosuppressive therapies sometimes lack efficacy and can lead to significant toxicities.

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Dec
1969

Many older adults have multiple conditions and see multiple providers, which may impact their use of essential medications.
We examined whether the number of prescribers of these medications was associated with the availability of medications, a surrogate for adherence, to manage diabetes, hypertension or dyslipidemia.
A retrospective cohort of 383,145 older adults with diabetes, hypertension or dyslipidemia in the US Medicare program living in 10 states.

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Dec
1969

Almost 80% of people have low back pain at least once in their life. Clinical guidelines emphasize the use of conservative physiotherapy and the importance of staying active. While the psychological factors predicting poor recovery following surgical intervention are understood, the psychosocial factors associated with poor outcomes following physiotherapy have yet to be identified.

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Dec
1969

Minimally invasive epiduroscopy has recently been reported as an effective treatment procedure for chronic and intractable low back pain. However, no study has determined safe anesthetics for monitored anesthesia care during epiduroscopy. We aimed to compare and evaluate conventional monitored anesthesia care drugs with dexmedetomidine.

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Dec
1969

Obesity-associated diabetes causes aging-like changes to skin physiology in animal models, but there have been no clinical studies focusing on human obese diabetic patients. The purpose of this study was to examine the hypothesis that obesity-associated diabetes accelerates aging-like skin changes in Japanese people.
This cross-sectional study enrolled obese-diabetes patients (body mass index ≥ 25 kg m-2) and healthy volunteers (body mass index < 25 kg m) as controls.

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Dec
1969

Tubular adenoma of the breast is one of the most rare benign neoplasms, accounting for only 0.13% to 1.7% of all breast benign tumors.

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Dec
1969

CNCM I-745 Improves Intestinal Enzyme Function: A Trophic Effects Review.

Clin Med Insights Gastroenterol 2018 9;11:1179552217752679. Epub 2018 Feb 9.
Margret I Moré, Yvan Vandenplas
Several properties of the probiotic medicinal yeastCNCM I-745 contribute to its efficacy to prevent or treat diarrhoea. Besides immunologic effects, pathogen-binding and anti-toxin effects, as well as positive effects on the microbiota,CNCM I-745 also has pronounced effects on digestive enzymes of the brush border membrane, known as trophic effects. The latter are the focus of this review.

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Dec
1969

Although a significant proportion of adults recover from substance use disorders (SUDs), little is known about how they reach this turning point or why they stop using. The purpose of the study was to explore the factors that influence reasoning and decision making about quitting substance use after a long-term SUD. Semistructured interviews were conducted with 18 participants, each of whom had been diagnosed with a SUD and had been abstinent for at least 5 years.

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Dec
1969

Using compound W (a 3,3'-diiodothyronine sulfate [TS] immuno-crossreactive material)-specific polyclonal antibodies and homogeneous time-resolved fluorescence immunoassay assay techniques (AlphaLISA) to establish an indirect competitive compound W (ICW) quantitative detection method.
Photosensitive particles (donor beads) coated with compound W or TS and rabbit anti-W antibody were incubated with biotinylated goat anti-rabbit antibody. This constitutes a detection system with streptavidin-coated acceptor particle.

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Dec
1969

The development of peripheral lymphoid tissues from the mesoderm is the result of a complex convergence combining lymphohematopoietic differentiation with the local specification of nonhematopoietic mesenchymal components. Although the various transcriptional regulators with fate-determining effects in diversifying the mobile leukocyte subsets have been thoroughly studied and identified, the tissue-specific determinants promoting the regional differentiation of resident mesenchyme are less understood. Of these factors, various members of the NK-class Nkx paralogues have emerged as key regulators for the organogenesis of spleen and mucosal lymphoid tissues, and recent data have also indicated their involvement in various pathological events, including gut inflammation and hematopoietic malignancies.

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Dec
1969

Prion protein (PrP) is a biomolecule that is involved in neuronal signaling, myelinization, and the development of neurodegenerative diseases. In the cell, PrP is shed by the ADAM10 protease. This process generates PrP molecules that lack glycophosphatidylinositol anchor, and these molecules incorporate into toxic aggregates and neutralize toxic oligomers.

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Dec
1969

Cancer is one of the major heterogeneous disease with high morbidity and mortality with poor prognosis. Elevated levels of reactive oxygen species (ROS), alteration in redox balance, and deregulated redox signaling are common hallmarks of cancer progression and resistance to treatment. Mitochondria contribute mainly in the generation of ROS during oxidative phosphorylation.

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Dec
1969

Understanding gene-gene interaction and its causal relationship to protein-protein interaction is a viable route for understanding drug action at the genetic level, which is largely hindered by inability to robustly map gene regulatory networks. Here, we use biological prior knowledge of family-to-family gene interactions available in the KEGG database to reveal individual gene-to-gene interaction networks that underlie the gene expression profiles of 2 cell line data sets, sensitive and resistive to neoadjuvant docetaxel breast anticancer drug. Comparison of the topology of the 2 networks revealed that the resistant network is highly connected with 2 large domains of connectivity: one in which the RAF1 and MAP2K2 genes form hubs of connectivity and another in which the RAS gene is highly connected.

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Dec
1969

In this paper we investigate recent Sleeping Beauties cited in patents (SB-SNPRs). We find that the increasing trend of the relative number of SBs stopped around 1998. Moreover, we find that the time lag between the publication year of the SB-SNPRs and their first citation in a patent is becoming shorter in recent years.

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Dec
1969

Journals were central to Eugene Garfield's research interests. Among other things, journals are considered as units of analysis for bibliographic databases such as the Web of Science and Scopus. In addition to providing a basis for disciplinary classifications of journals, journal citation patterns span networks across boundaries to variable extents.

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Feb
2018

The original version of this Article contained an error in the spelling of the author Benjamin H. Williams, which was incorrectly given as Benjamin H. Willams.

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Feb
2018

In the original version of this Article, the third sentence of the first paragraph of the "Changes in the input of polar waters into the Labrador Sea" section of the Results originally incorrectly read 'During the spring-summer months, after the winter convection has ceased in the Labrador Sea, its northwest boundary currents (the EGC and IC) support restratification of the surface ocean through lateral transport.' The correct version states 'northeast' instead of 'northwest'. The fifth sentence of the second paragraph of the same section originally incorrectly read "In contrast, in the western section of the Nordic Seas, under the presence of warm Atlantic waters of the Norwegian Current, Nps was found to calcify deeper in the water column (100-200 m), whereas in the east under the influence of the EGC polar waters it calcified closer to the surface at a similar depth as Tq.

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Feb
2018


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