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Author: A Rickinson (331)


Oct
2017

Epstein-Barr virus-associated lymphomas.

Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1732)
Claire Shannon-Lowe, Alan B Rickinson, Andrew I Bell
Epstein-Barr virus (EBV), originally discovered through its association with Burkitt lymphoma, is now aetiologically linked to a remarkably wide range of lymphoproliferative lesions and malignant lymphomas of B-, T- and NK-cell origin. Some occur as rare accidents of virus persistence in the B lymphoid system, while others arise as a result of viral entry into unnatural target cells. The early finding that EBV is a potent B-cell growth transforming agent hinted at a simple oncogenic mechanism by which this virus could promote lymphomagenesis.

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Nov
2017

Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. In contrast, infection later in life often leads to infectious mononucleosis (IM), a febrile illness characterized by anti-EBV IgM antibody positivity, high loads of circulating latently infected B cells, and a marked lymphocytosis caused by hyperexpansion of EBV-specific CD8T cells plus a milder expansion of CD56NKG2AKIRnatural killer (NK) cells. How the two situations compare is unclear due to the paucity of studies on clinically silent infection.

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Dec
1969

The EBV is known to persist in memory B cells, but it remains unclear how this affects cell numbers and humoral immunity. We here studied EBV persistence in memory B cell subsets and consequences on B cell memory in young children. EBV genome loads were quantified in 6 memory B cell subsets in EBVadults.

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