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Author: Bob O Vogel (2)


Sep
2017

The rs1625579 variant near the microRNA-137 (MIR137) gene is one of the best-supported schizophrenia variants in genome-wide association studies (GWAS), and microRNA-137 functionally regulates other GWAS identified schizophrenia risk variants. Schizophrenia patients with the MIR137 rs1625579 risk genotype (homozygous for the schizophrenia risk variant) also have aberrant brain structure. It is unclear if the effect of MIR137 among schizophrenia patients is due to potential epistasis with genetic risk for schizophrenia or other factors of the disorder.

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Sep
2015

In the predictive coding framework, mismatch negativity (MMN) is regarded a correlate of the prediction error that occurs when top-down predictions conflict with bottom-up sensory inputs. Expression-related MMN is a relatively novel construct thought to reflect a prediction error specific to emotional processing, which, however, has not yet been tested directly. Our paradigm includes both neutral and emotional deviants, thereby allowing for investigating whether expression-related MMN is emotion-specific or unspecifically arises from violations of a given sequence.

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