Helping You Find Full Text Journal Articles

Search Results:

Author: Christian L Seifert (17)


Feb
2018

Background We have recently shown that the presence of headache in ischemic stroke is associated with lesions of the insular cortex. The aim of this post-hoc subgroup analysis was to investigate the association of specific headache features with stroke location in patients with acute ischemic stroke. Methods In this observational study, patients (mean age: 61.

View Full Text PDF Listings View primary source full text article PDFs.

Jan
2016

Headache is a common symptom in acute ischaemic stroke, but the underlying mechanisms are incompletely understood. The aim of this lesion mapping study was to identify brain regions, which are related to the development of headache in acute ischaemic stroke. Patients with acute ischaemic stroke (n = 100) were assessed by brain MRI at 3 T including diffusion weighted imaging.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2015

The thalamus contains third-order relay neurons of the trigeminal system, and animal models as well as preliminary imaging studies in small cohorts of migraine patients have suggested a role of the thalamus in headache pathophysiology. However, larger studies using advanced imaging techniques in substantial patient populations are lacking. In the present study, we investigated changes of thalamic volume and shape in a large multicenter cohort of patients with migraine.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2016

Anterior spinal artery syndrome (ASAS) often leads to complete motor paralysis with poor clinical outcome. There is a lack of controlled clinical trials on acute treatment strategies in ASAS. However, systemic thrombolysis with recombinant tissue-plasminogen activator (rt-PA) might be a useful therapeutic option in ASAS.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2015

Antiphospholipid antibody syndrome (APS) is usually a disease of young adults. In elderly stroke patients APS was not associated with progressive intracerebral stenosis in the past. Here, we report a 65-year-old patient who presented with recurrent ischemic strokes associated with progressive stenosis of the right middle cerebral artery.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
2015

The neural mechanisms of heroin addiction are still incompletely understood, even though modern neuroimaging techniques offer insights into disease-related changes in vivo. While changes on cortical structure have been reported in heroin addiction, evidence from subcortical areas remains underrepresented. Functional imaging studies revealed that the brain reward system and particularly the nucleus accumbens (NAcc) play a pivotal role in the pathophysiology of drug addiction.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Progenitor cells (PCs) contribute to the endogenous repair mechanism after ischemic events. Interleukin-8 (IL-8) as part of the acute inflammatory reaction may enhance PC mobilization. Also, statins are supposed to alter number and function of circulating PCs.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2013

We here report the case of a patient who previously underwent posterior fossa surgery and was later treated with greater occipital nerve blockade for unilateral facial pain. The patient went into coma immediately post-injection but made a full recovery without sequelae after intensive care treatment. Physicians should be aware of the risks of greater occipital nerve blockade after previous posterior fossa craniotomy.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Although a relationship between depression and cardiovascular events has been suggested, past study results regarding the risk of stroke in relation to depression by subgroups are ambiguous. The aim of this study was to investigate the influence of depressive symptoms on risk of incident ischemic stroke in elderly according to age and sex. This prospective cohort study followed up 3852 subjects older than 55 years.

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2012

Atrial fibrillation and chronic kidney disease.

N Engl J Med 2012 Nov;367(22):2157-8; author reply 2158-9
Marcus Baumann, Christian L Seifert, Holger Poppert

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2012

This study aims at investigating cortical thickness in cluster headache patients as compared with a healthy control group.
The pathobiology of cluster headache is not yet fully understood, although a dysfunction of the hypothalamus has been suggested to be causal. Previous studies in migraine and trigeminal neuropathic pain have demonstrated changes in cortical thickness using cortex segmentation techniques, but no data have been published on cluster headache.

View Full Text PDF Listings View primary source full text article PDFs.

Aug
2012

Central post-stroke pain of thalamic origin is an extremely distressing and often refractory disorder. There are no well-established predictors for pain development after thalamic stroke, and the role of different thalamic nuclei is unclear. Here, we used structural magnetic resonance imaging to identify the thalamic nuclei, specifically implicated in the generation of central post-stroke pain of thalamic origin.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2012

We report a case of multiple sclerosis-associated fulminant tumefactive demyelinating lesion (TDL) with the special feature of delayed humoral immune response. Plasma exchange (PE) yielded significant benefit in two consecutive steroid-unresponsive relapses, while signs of an intrathecal B-cell response were only present 2 years later at the second relapse. Remission was achieved and sustained thereafter with natalizumab.

View Full Text PDF Listings View primary source full text article PDFs.

View Full Text PDF Listings View primary source full text article PDFs.

May
2011

Thrombolysis with recombinant tissue plasminogen activator in the treatment of acute ischemic stroke carries a long list of contraindications. One of these is recent surgery, but the extent of complications after minor surgeries such as dental extraction or oral surgical procedures is unclear. Here, we report the management of 2 cases with accidental bleeding from the oral cavity during systemic thrombolysis in ischemic stroke because of recent unreported oral surgery.

View Full Text PDF Listings View primary source full text article PDFs.

Jan
2011

A close association between pain, depression and disability has been shown. However, the neurometabolic correlates of this association have been barely investigated in disease states. Episodic cluster headache is a severe headache syndrome and represents a suitable disease model for the investigation of episodic pain.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2008

Pineal cysts have been suggested to be linked to headache pathogenesis. However, no systematic studies on this topic have been performed so far.
The aim of this study was to investigate the relationship between pineal cysts and headache and to determine the relevance of the cyst size in this context.

View Full Text PDF Listings View primary source full text article PDFs.

Back to top