Helping You Find Full Text Journal Articles

Search Results:

Author: Edward D Barker (66)


Dec
2017

Growing evidence supports the existence of two variants of youth with high callous-unemotional (CU) traits who present with markedly different risk profiles and outcomes, with potential implications for risk assessment and treatment formulation. So far, studies have identified variants of CU youth mainly using data-driven cluster approaches based on levels of CU traits and co-occurring anxiety. Yet, the extent to which this knowledge may be translated into clinical practice is unclear.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
2017

Emerging research in epigenetics has shown that there is variability in how environmental exposures "get under the skin" through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social-cognitive processes that may underlie a wide range of childhood psychopathology.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2017

Previous studies have shown that both pre- and post-natal adversities, the latter including exposures to stress during childhood and adolescence, explain variation in structural properties of white matter (WM) in the brain. While previous studies have examined effects of independent stress exposures within one developmental period, such as childhood, we examine effects of stress across development using data from a prospective longitudinal study. More specifically, we ask how stressful events during prenatal development, childhood, and adolescence relate to variation in WM properties in early adulthood in young men recruited from a birth cohort.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2017

There is increasing evidence that youth who follow the early onset persistent (EOP), adolescent-onset (AO) and childhood-limited (CL) trajectories of conduct problems show varying patterns of health, mental health, educational, and social outcomes in adulthood. However, there has been no systematic review and meta-analysis on outcomes associated with different conduct problems trajectories. We systematically reviewed the literature of longitudinal studies considering outcomes of three conduct problems trajectories: EOP, AO, and CL compared with individuals with low levels of conduct problems (low).

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2017

In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2017

DNA methylation (DNAm) is a potential mechanism for propagating the effects of environmental exposures on child and adolescent mental health. In recent years, this field has experienced steady growth.
We provide a strategic review of the current child and adolescent literature to evaluate evidence for a mediating role of DNAm in the link between environmental risks and psychopathological outcomes, with a focus on internalising and externalising difficulties.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships.
Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains and functional MRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions.

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2017

Early-onset conduct problems (CP) are a key predictor of adult criminality and poor mental health. While previous studies suggest that both genetic and environmental risks play an important role in the development of early-onset CP, little is known about potential biological processes underlying these associations. In this study, we examined prospective associations between DNA methylation (cord blood at birth) and trajectories of CP (4-13 years), using data drawn from the Avon Longitudinal Study of Parents and Children.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
2017

The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2017

Emotional eating, that is, eating more in response to negative mood, is often seen in children. But the origins of emotional eating remain unclear. In a representative community sample of Norwegian 4-year-olds followed up at ages 6, 8, and 10 years (analysis sample: n = 801), one potential developmental pathway was examined: a reciprocal relation between parental emotional feeding and child emotional eating.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2017

Growing evidence suggests heterogeneity within interpersonal-callous (IC) youth based on co-occurring anxiety. The developmental validity of this proposed taxonomy remains unclear however, as most previous research is cross-sectional and/or limited to adolescence. We aimed to identify low-anxiety (IC/ANX-) and high-anxiety (IC/ANX+) IC variants, and compare these groups on (a) early risk exposures, (b) psychiatric symptoms from midchildhood to early adolescence, and (c) school-based functioning.

View Full Text PDF Listings View primary source full text article PDFs.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2017

Little is known about early life diet as a risk factor for early-onset persistent conduct problems (EOP CP). To investigate this, we used data from the Avon Longitudinal Study of Parents and Children, a UK-based prospective epidemiological birth cohort. 5727 mother-child pairs (49.

View Full Text PDF Listings View primary source full text article PDFs.

Jan
2017

Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to 'unhealthy diet'. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Prenatal maternal stress exposure has been associated with neonatal differential DNA methylation. However, the available evidence in humans is largely based on candidate gene methylation studies, where only a few CpG sites were evaluated. The aim of this study was to examine the association between prenatal exposure to maternal stress and offspring genome-wide cord blood methylation using different methods.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2015

Early adversity is an important risk factor that relates to internalizing symptoms and altered brain structure.
To assess the direct effects of early adversity and child internalizing symptoms (ie, depression, anxiety) on cortical gray matter (GM) volume, as well as the extent to which early adversity associates with variation in cortical GM volume indirectly via increased levels of internalizing symptoms.
A prospective investigation of associations between adversity within the first 6 years of life, internalizing symptoms during childhood and early adolescence, and altered brain structure in late adolescence (age, 18-21 years) was conducted in a community-based birth cohort in England (Avon Longitudinal Study of Parents and Children).

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2016

In the present study, we report on the development and initial psychometric properties of the Family Aggression Screening Tool (FAST). The FAST is a brief, self-report tool that makes use of pictorial representations to assess experiences of caregiver aggression, including direct victimization and exposure to intimate partner violence. It is freely available on request and takes under 5 minutes to complete.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2015

The authors tested three possible pathways linking prenatal maternal depressive symptoms to adolescent depressive symptoms. These pathways went through childhood Irritability Symptoms, Anxiety/Depressive Symptoms or Conduct Problems.
Data were collected from 3,963 mother-child pairs participating in the Avon Longitudinal Study of Parents and Children.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2015

Peer victimization is a common and pervasive experience in childhood and adolescence and is associated with various maladjustment symptoms, including internalizing, externalizing, and somatic problems. This variety suggests that peer victimization is multifinal where exposure to the same risk leads to different outcomes. However, very little is known about the relative likelihood of each form of maladjustment.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2014

Peer antisocial behavior robustly predicts adolescents' own behavior but not all adolescents are equally vulnerable to their peers' influence and genetic factors may confer vulnerability. This study used data of= 3081 adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) to examine whether, a polymorphism that affects psychological functioning, moderates the association between affiliation with aggressive peers at age 10 and own aggression at age 15. A significant gene-environment interaction was found, where those who affiliated with aggressive peers in childhood showed increased risk for being aggressive in adolescence if they carried themet-met variant compared to val-val carriers.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2014

Delinquency and substance use (SU) are commonly comorbid during adolescence. In the present study we investigate this co-morbidity with 3 main objectives: 1. Evaluate reciprocal relationships between delinquency/SU across early adolescence.

View Full Text PDF Listings View primary source full text article PDFs.

May
2014

Developmental or fetal programming has emerged as a major model for understanding the early and persisting effects of prenatal exposures on the health and development of the child and adult. We leverage the power of a 14-year prospective study to examine the persisting effects of prenatal anxiety, a key candidate in the developmental programming model, on symptoms of behavioral and emotional problems across five occasions of measurement from age 4 to 13 years. The study is based on the Avon Longitudinal Study of Parents and Children cohort, a prospective, longitudinal study of a large community sample in the west of England (n = 7,944).

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2014

Childhood maltreatment is a key risk factor for maladjustment and psychopathology. Although maltreated youth are more likely to experience community violence, both forms of adversity are generally examined separately. Consequently, little is known about the unique and interactive effects that characterize maltreatment and community violence exposure (CVE) on mental health.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
2013

Little is currently known about how maternal depression symptoms and unhealthy nutrition during pregnancy may developmentally interrelate to negatively affect child cognitive function.
To test whether prenatal maternal depression symptoms predict poor prenatal nutrition, and whether this in turn prospectively associates with reduced postnatal child cognitive function.
In 6979 mother-offspring pairs participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) in the UK, maternal depression symptoms were assessed five times between 18 weeks gestation and 33 months old.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2014

Maternal depression and contextual risks (e.g. poverty) are known to impact children's cognitive and social functioning.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2013

To test the developmental continuity, interrelationships, and predictive associations of the oppositional defiant disorder (ODD) subdimensions of irritable, headstrong, and hurtful.
Data were collected from 6,328 mother-child pairs participating in the Avon Longitudinal Study of Parents and Children (United Kingdom).
Developmental continuity for each subdimension was strong and interrelationships indicated that headstrong was associated mainly with irritable, whereas irritable did not cross associate with other ODD subdimensions; and hurtful was associated with lower levels of headstrong.

View Full Text PDF Listings View primary source full text article PDFs.

Aug
2013

To examine the validity of a growth trajectory method to discriminate between pathologically and constitutionally undergrown fetuses using repeated measures of estimated fetal weight.
In a prospective, observational, multicenter study in Ireland, 1,116 women with a growth-restricted fetus diagnosed participated with the objective of evaluating ultrasound findings as predictors of pediatric morbidity and mortality. Fetal growth trajectories were based on estimated fetal weight.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
2013

To investigate the prevalence of cannabis use and problem use in boys and girls at age 16 years, and to investigate the role of adversity in early life and of conduct disorder between the ages of 4 and 13 years as risk factors for these outcomes.
Birth cohort study.
England.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Although only few studies have shown direct links between dopaminergic system genes and smoking onset, this does not rule out the effect of a gene-environment interaction on smoking onset. Therefore, the aim of this study was to examine the associations between smoking-specific parenting (i.e.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2013

The researchers longitudinally assessed parent and child levels of engagement in an evidence-based preventive intervention for children. The sample included 114 fifth graders with aggressive, disruptive behaviors and their parents who participated in the Coping Power Program. Findings indicate that levels of engagement differentially fluctuated for children and parents throughout the course of the intervention.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Both environmental risk and genetic variation is believed to play a role in substance use. A candidate environmental variable is parenting. Recent studies have found support for the idea that the dopamine system affects the susceptibility to environmental influences.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2013

Psychopathy and depression have rarely been studied together despite relatively high rates of both in court-referred adolescent samples. To determine if youth high in psychopathy and depression experience more psychosocial difficulties, the current study examined psychopathy and depression in 103 adolescent offenders using two well-validated assessments: The Psychopathy Checklist-Youth Version (PCL-YV; Forth, Kosson, & Hare, 1996/2003) and the depression scale of the Adolescent Psychopathology Scale (APS; Reynolds, 1998). Findings showed that psychopathy and depression interact to statistically predict much higher levels of anger, aggression, interpersonal problems, and substance use.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2012

Harsh parenting practices and negative parental feelings may be environmental risk factors for low self-control in children. Children may also evoke certain parenting reactions.
To investigate the longitudinal relationship between parenting and self-control, as well as associated outcomes within the monozygotic (MZ) twin differences framework.

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2012

Irritability is a subdimension of ODD, which predicts mainly to internalizing disorders, and to a lesser extent, conduct problems and callous-unemotional traits. Given that youth with similar dispositions as the irritable types - as well as youth high in callous-unemotional (CU) traits - have both been reported to experience high levels of victimization by peers, the authors examined an extension of the failure model (Patterson & Capaldi, 1990): that irritability increases peer victimization, which, in turn, predicts both CU and internalizing symptoms.
Using data from 5,923 mother-child pairs participating in The Avon Longitudinal Study of Parents and Children, the authors tested the outcomes of internalizing difficulties and callous-unemotional traits (based on mother report at age 13) via the predictors (at ages 8 and 10) of irritability (mother report) and the experience of peer victimization (youth report).

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2012

This study explored whether early elementary school aged children's externalizing problems impede academic functioning and foster negative social experiences such as peer victimization, thereby making these children vulnerable for developing internalizing problems and possibly increasing their externalizing problems. It also explored whether early internalizing problems contributed to an increase in externalizing problems. The study examined 1,558 Canadian children from ages 6 to 8years.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2013

Few studies have examined the item functioning of youth psychopathy measures or compared the functioning of clinician and self-report based indices. Even fewer studies have made these comparisons in both male and female adolescent samples. The present study examined the applicability of items from two psychopathy measures, the Antisocial Process Screening Device (APSD; Frick, P.

View Full Text PDF Listings View primary source full text article PDFs.

Jan
2013

The present study investigated longitudinal associations and bidirectional influences between family members in smoking behavior using a longitudinal full-family design. Family systems provide a powerful social context in which modeling and imitation take place. In current literature, however, bidirectional associations between parents and children in smoking behavior are seldom considered.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2012

In general, mothers with depression experience more environmental and family risk factors, and lead riskier lifestyles, than mothers who are not depressed.
To test whether the exposure of a child to risk factors associated with mental health adds to the prediction of child psychopathology beyond exposure to maternal depression.
In 7429 mother-offspring pairs participating in the Avon Longitudinal Study of Parents and Children in the UK, maternal depression was assessed when the children were aged 1.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2012

  This study aimed to identify the pathways through which a preventive intervention targeting young low-SES disruptive boys could result in lower crime involvement during adulthood.
  The preventive intervention was implemented when the children were between 7 and 9 years and included three components (i.e.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2012

Aggressive behavior in middle childhood is at least partly explained by genetic factors. Nevertheless, estimations of simple effects ignore possible gene-environment interactions (G × E) or gene-environment correlations (rGE) in the etiology of aggression. The present study aimed to simultaneously test for G × E and rGE processes between aggression, on the one hand, and peer victimization and the teacher-child relationship in school, on the other hand.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2013

Using a genetically informed design, this study examined the additive and interactive effects of genetic risk, personal peer victimization experiences, and peer victimization experienced by others on children's aggression and depression symptoms. Of major interest was whether these effects varied depending on whether or not the victimized others were children's close friends. The sample comprised 197 monozygotic and same-sex dizygotic twin pairs reared together (95 female pairs) assessed in Grade 4.

View Full Text PDF Listings View primary source full text article PDFs.

Aug
2011

The adverse effect of both pre- and post-natal maternal anxiety and depression on the development of offspring is shown by a large body of research. No published studies, however, have simultaneously: (i) controlled for co-occurring prenatal risks that may influence maternal prenatal anxiety and depression; (ii) compared the relative contributions of prenatal and postnatal maternal anxiety and depression on child functioning; and (iii) assessed a full range of child psychopathology and functioning to determine the relative effects of prenatal and postnatal anxiety and depression in the mother.
Using 3,298 mother-offspring pairs, the authors examined these factors in a single-path analytic model.

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2011

Using the differential susceptibility perspective (Belsky & Pluess, 2009) as a guiding frame-work, age 12 neighborhood disadvantage (ND) and family characteristics (parental knowledge) were examined as moderators of the relations between age 12 youth impulsivity and the development (ages 13, 14, and 15) of positive (community activities) and negative (antisocial behavior; ASB) adolescent behavior. An interaction between ND and youth impulsivity (age 12) operated with differential susceptibility, but only for female community activities at age 13: under low levels of ND, impulsive adolescent females engaged in the highest levels of community activities, whereas under high ND, they engaged in the lowest levels. Exploratory analysis showed the association between community activities and ND to be partially related to parents' or adults' engagement in informal social controls (e.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2011

DSM-IV specifies three ADHD subtypes; the combined, the hyperactive-impulsive and the inattentive. Little is known about the developmental relationships underlying these subtypes. The objective of this study was to describe the development of parent-reported hyperactivity-impulsivity and inattention symptoms from childhood to adolescence and to study their associations with genetic factors, family risk, and later adjustment problems in early adulthood.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2011

To estimate associations between trajectories of conduct problems and social-cognitive competences through childhood into early adolescence.
A prospective population-based cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC) recruited in the prenatal period (13,988 children alive at 12 months) formed the basis for the current study. Socio-emotional and pragmatic language competences were examined in relation to conduct problem development in a group of 6,047 children with no known autistic-spectrum disorders.

View Full Text PDF Listings View primary source full text article PDFs.

Aug
2011

Proposals have been submitted to the DSM-V for the addition of a callous-unemotional (CU) specifier for conduct problem (CP) youth (CP/CU). While the addition of such a diagnostic category may aid in the identification of homogeneous CP subtypes, evidence on risks for the development of CP/CU remains limited. The present study sought to examine the extent to which CP/CU in early adolescence could be differentiated by family- and child-based risks from pregnancy to age 4 years.

View Full Text PDF Listings View primary source full text article PDFs.

May
2011

Children growing up in disharmonious families with anxious/depressed mothers are at risk for emotional and behavioral difficulties, however whether these associations reflect postnatal environment, prenatal exposure, or an overall liability is still unclear. This study used prospectively collected data from 24,259 participants of the Norwegian Mother and Child Cohort Study (MoBa). Mothers reported on anxiety/depression and family disharmony twice in pregnancy and twice post pregnancy, as well as on their child's physical aggression and crying behavior at age 36 months.

View Full Text PDF Listings View primary source full text article PDFs.

May
2011

There is growing evidence that among the different conduct disorder (CD) behaviors, physical aggression, but not theft, links to low neurocognitive abilities. Specifically, physical aggression has consistently been found to be negatively related to neurocognitive abilities, whereas theft has been shown to be either positively or not related to neurocognition. The specificity of these links needs further examination because attention deficit hyperactivity disorder (ADHD) links to both physical aggression and neurocognitive variation.

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2010

It is increasingly recognized that youth who follow early onset persistent (EOP), childhood limited (CL) and adolescent onset (AO) trajectories of conduct problems show somewhat varying patterns of risk (in childhood) and adjustment problems (in adolescence and adulthood). Little, however, is known about how other adjustment problems differentially co-develop with the EOP, CL and AO trajectories across the childhood and adolescent years.
Using data from the Avon Longitudinal Study of Parents and Children, an epidemiological, longitudinal cohort of boys and girls, we estimated growth curves for parent-reported hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors conditional on trajectories of conduct problems (i.

View Full Text PDF Listings View primary source full text article PDFs.

Aug
2010

The present study (a) tests main and moderational effects of neighborhood and family risk, and adolescent impulsivity on the development of male and female antisocial behavior (ASB) and (b) examines the extent to which these effects work indirectly through parental knowledge. Adolescents (N = 4,597; 51% male) reported on informal social control in their neighborhoods, their family types, and impulsivity at age 12, and on parental monitoring and ASB at ages 13 and 15 years. Neighborhoods were further defined as risk and nonrisk in economic deprivation by census-level data.

View Full Text PDF Listings View primary source full text article PDFs.

Back to top