Author: Emily E Biliouris (1)
Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein.Cell Mol Life Sci 2016 Jan 22;73(1):201-15. Epub 2015 Jul 22.Amandine Grimm, Emily E Biliouris, Undine E Lang, Jürgen Götz, Ayikoe Guy Mensah-Nyagan, Anne Eckert
Alzheimer's disease (AD) is an age-related neurodegenerative disease marked by a progressive cognitive decline. Metabolic impairments are common hallmarks of AD, and amyloid-β (Aβ) peptide and hyperphosphorylated tau protein--the two foremost histopathological signs of AD--have been implicated in mitochondrial dysfunction. Neurosteroids have recently shown promise in alleviating cognitive and neuronal sequelae of AD.
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