Helping You Find Full Text Journal Articles

Search Results:

Author: Kelly A Dougherty (18)


Dec
2016

Pancreatic enzyme therapy does not normalize dietary fat absorption in patients with cystic fibrosis and pancreatic insufficiency. Efficacy of LYM-X-SORB (LXS), an easily absorbable lipid matrix that enhances fat absorption, was evaluated in a 12-month randomized, double-blinded, placebo-controlled trial with plasma fatty acids (FA) and coefficient of fat absorption (CFA) outcomes. A total of 110 subjects (age 10.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
2014

Suboptimal vitamin D (vitD) status is common in children and young adults infected with human immunodeficiency virus (HIV). The vitD supplemental dose needed to normalize vitD status in this population is unknown.
In this double-blind trial, subjects infected with HIV ages 8.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2016

Choline depletion is seen in cystic fibrosis (CF) and pancreatic insufficiency in spite of enzyme treatment and may result in liver, fatty acid, and muscle abnormalities. This study evaluated the efficacy and safety of an easily absorbed choline-rich structured lipid (LYM-X-SORB™ [LXS]) to improve choline status.
Children with CF and pancreatic insufficiency were randomized to LXS or placebo in a 12-month double blind trial.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2015

Suboptimal vitamin D (vit D) status (<32 ng/mL) is ubiquitous among African American children with type SS sickle cell disease (SCD-SS). The vit D supplemental dose to normalize vit D status is unknown. Five to 20-year-old African American children with (n=21) and without (n=23) SCD-SS were randomized to vit D3 supplementation (4000 or 7000 IU/d) and evaluated at 6 and 12 weeks for changes in vit D and SCD status.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2015

Suboptimal vitamin D status is prevalent in HIV-infected patients and associated with increased risk of disease severity and morbidity. We aimed to determine 12-month safety and efficacy of daily 7000 IU vitamin D3 (vitD3) versus placebo to sustain increased serum 25-hydroxyvitamin D (25(OH)D) and improve immune status in HIV-infected subjects.
This was a double-blind trial of perinatally acquired HIV (PHIV)-infected subjects or behaviorally acquired HIV (BHIV)-infected subjects (5.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2014

The study aim was to determine the effect of a dietary intervention on growth, body composition and resting energy expenditure (REE) in children with cystic fibrosis (CF) and pancreatic insufficiency (PI) in a randomized, double blind, placebo-controlled trial.
Subjects (5 to 17 yrs) participated in a 12-month trial of the organized lipid matrix LYM-X-SORB™ (LXS) vs. placebo dietary supplements with similar calories, total fat and fatty acids.

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2014

Unexpectedly high serum B12 concentrations were noted in most study subjects with cystic fibrosis (CF) and pancreatic insufficiency (PI) participating in a nutrition intervention at the baseline evaluation. The objectives of this study were to determine dietary, supplement-based, and enzyme-based B12 intake, serum B12 concentrations, and predictors of vitamin B12 status in children with CF and PI.
Serum B12 status was assessed in subjects (5-18 years) and categorized as elevated (serum B12 above reference range for age and sex [Hi-B12]) or within reference range (serum B12 within reference range for age and sex) for age and sex.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2014

The aim of the study was to assess the impact of LYM-X-SORB (LXS), an organized lipid matrix that has been shown to be absorbable without pancreatic enzyme therapy on fat-soluble vitamin status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI).
Children with CF and PI were randomized to daily LXS or an isocaloric placebo comparison supplement for 12 months. Serum vitamins A (retinol), D (25-hydroxyvitamin D[25D]), E (α-tocopherol, α-tocopherol:cholesterol ratio), and K (percentage of undercarboxylated osteocalcin [%ucOC] and plasma proteins induced by vitamin K absence factor II [PIVKA II]) were assessed at baseline and 12 months.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2013

The rodent hippocampus can be divided into dorsal (DHC) and ventral (VHC) domains on the basis of behavioral, anatomical, and biochemical differences. Recently, we reported that CA1 pyramidal neurons from the VHC were intrinsically more excitable than DHC neurons, but the specific ionic conductances contributing to this difference were not determined. Here we investigated the hyperpolarization-activated current (I(h)) and the expression of HCN1 and HCN2 channel subunits in CA1 pyramidal neurons from the DHC and VHC.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2013

Optimal vitamin D status is known to have beneficial health effects and vitamin D supplements are commonly used. It has been suggested that vitamin D supplementation may increase blood lead in children and adults with previous lead exposure. The objective was to determine the safety regarding lead toxicity during 12 weeks of high-dose vitamin D3 supplementation in children and young adults with human immunodeficiency virus (HIV).

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2012

The hippocampus has a central role in learning and memory. Although once considered a relatively homogenous structure along the longitudinal axis, it has become clear that the rodent hippocampus can be anatomically and functionally divided into a dorsal component generally associated with spatial navigation, and a ventral component primarily associated with non-spatial functions that involve an emotional component. The ventral hippocampus (VHC) is also more sensitive to epileptogenic stimuli than the dorsal hippocampus (DHC), and seizures tend to originate in the VHC before spreading to other brain regions.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2012

Suboptimal vitamin A status is prevalent in children with type SS sickle cell disease (SCD-SS) and is associated with hospitalizations and poor growth and hematologic status. The supplemental vitamin A dose that optimizes suboptimal vitamin A status in this population is unknown.
The efficacy of Recommended Dietary Allowance (RDA) doses (based on age and sex) of vitamin A (300, 400, or 600 μg retinyl palmitate/d) or vitamin A + zinc (10 or 20 mg zinc sulfate/d) compared with placebo to optimize vitamin A status was assessed in children aged 2.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2011

Dominant hand maximal handgrip strength evaluated with a handgrip dynamometer and peak power evaluated with a force plate, adjusted for body size and composition, were compared in African-American children aged 5 to 13 years, with and without type SS sickle cell disease (SCD-SS). Children with SCD-SS (n = 35; age, 9.0 ± 2.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2010

For children and adolescents with cystic fibrosis (CF) and pancreatic insufficiency, the efficacy of routine vitamin K supplementation to normalize vitamin K status remains unclear.
This study examined and determined predictors of vitamin K status in subjects aged 8-25 y with CF and pancreatic insufficiency taking various vitamin K supplements.
In 97 subjects, serum 25-hydroxyvitamin D [25(OH)D], dietary intake, vitamin K supplement intake, and vitamin K statusmdashdetermined on the basis of the percentage of serum undercarboxylated osteocalcin (%ucOC; sufficient: lt 20%) and plasma proteins induced by vitamin K absence-factor II (PIVKA-II; n = 60; sufficient: le 2 microg/L)mdashwere assessed.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2009

To determine the degree of natural acclimatization and artificially induced acclimation-related changes during repeated exercise in the heat bouts in seven lean and seven obese 9- to 12-yr-old boys during summer months.
Beginning at random times during the summer, subjects underwent a 70-min exercise (30% VO(2max)) in the heat exposure (38 degrees C, 50% relative humidity) on six separate days.
On day 1, obese children were less naturally acclimatized as indicated by significantly higher baseline core temperatures (T(c)) (obese = 37.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2007

To determine the effect of 1, 2, 3, and 4% dehydration (DEH) versus euhydration (EUH) on basketball performance in adult male players.
Seventeen 17- to 28-yr-old male basketball players completed 3 h of interval treadmill walking (40 degrees C and 20% relative humidity) with or without fluid replacement. Subjects completed six trials in random order: 1) EUH with a carbohydrate-electrolyte solution (CES), 2) EUH control (flavored water with 0% carbohydrate and 18 mM sodium), 3) 1% DEH, 4) 2% DEH, 5) 3% DEH, and 6) 4% DEH.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2007

The purpose of this study was to determine whether chronic energy deficiency achieved with caloric restriction combined with exercise is associated with changes in the 24-hour profile of ghrelin in non-obese, pre-menopausal women.
Twelve non-obese (BMI = 18 to 25 kg/m(2)), non-exercising women (age, 18 to 24 years) were randomly assigned to a non-exercising control group or a diet and exercise group. The 3-month diet and exercise intervention yielded a daily energy deficit of -45.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2006

To determine the effects of exercise heat-induced two percent dehydration (DEH) and euhydration (EUH) with a six percent carbohydrate-electrolyte solution (CES) compared with placebo EUH (P EUH) on basketball skills in skilled young players.
Fifteen 12- to 15-yr-old boys underwent three separate 2-h exercise heat exposures (double blind, random order): 2% DEH by limiting fluid intake during exercise in the heat and basketball skill drills, EUH (no net weight change) with a 6% CES, and EUH with a flavored water placebo (P EUH). After recovery, subjects performed an orchestrated sequence of continuous basketball drills designed to simulate a game (12-min quarters + a 10-min halftime).

View Full Text PDF Listings View primary source full text article PDFs.

Back to top