Author: Lok Wai Cola Ho (1)
Lok Wai Cola Ho, Wing-Yin Yung, Kwun Hei Samuel Sy, Ho Yin Li, Chun Kit K Choi, Ken Cham-Fai Leung, Thomas W Y Lee, Chung Hang Jonathan Choi
Alkyl groups (CH) are prevalent in engineered bionanomaterials used for many intracellular applications, yet how alkyl groups dictate the interactions between nanoparticles and mammalian cells remains incomprehensively investigated. In this work, we report the effect of alkylation on the cellular uptake of densely polyethylene glycol-coated nanoparticles, which are characterized by their limited entry into mammalian cells. Specifically, we prepare densely PEGylated gold nanoparticles that bear alkyl chains of varying carbon chain lengths (n) and loading densities (termed "alkyl-PEG-AuNPs"), followed by investigating their uptake by Kera-308 keratinocytes.
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