Helping You Find Full Text Journal Articles

Search Results:

Author: Paul Gellert (41)


Dec
1969

To test whether the negative relationship between perceived stress and quality of life (Hypothesis 1) can be buffered by perceived social support in patients with dementia as well as in caregivers individually (Hypothesis 2: actor effects) and across partners (Hypothesis 3: partner effects and actor-partner effects).
A total of 108 couples (N = 216 individuals) comprised of one individual with early-stage dementia and one caregiving partner were assessed at baseline and one month apart. Moderation effects were investigated by applying linear mixed models and actor-partner interdependence models.

View Full Text PDF Listings View primary source full text article PDFs.

Jan
2018

Information and Communication Technologies (ICTs) could be useful for delivering non-pharmacological therapies (NPTs) for dementia in nursing home settings.
To identify technology-related expectations and inhibitions of healthcare professionals associated with the intention to use ICT-based NPTs.
Cross-sectional multi-method survey.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2017

Multimorbidity in centenarians is common; although investigations of the prevalence of morbidity in centenarians are accumulating, research on profiles of co-occurrence of morbidities is still sparse. Our aim was to explore profiles of comorbidities in centenarians.
Health insurance data from 1,121 centenarians comprising inpatient and outpatient diagnoses from the past 5 years (2009-2013) were analyzed using latent class analysis with adjustments for sex, age, hospitalization, and long-term care.

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2017

While compression of morbidity has now been studied in multiple cohorts, we hypothesize that centenarians might also have fewer chronic conditions as well. We assume that individuals who die as centenarians have less comorbidities and have a less steep rise of the number of comorbidities over the final years before death compared to those who died as nonagenarians (90-99 years) or octogenarians (80-89 years of age).
This German cohort study used health insurance data.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2017

A small library of thermoresponsive amphiphilic copolymers based on polylactide-block-poly((2-(2-methoxyethoxy)ethyl methacrylate)-co-(oligoethylene glycol methacrylate)) (PLA-b-P(DEGMA)-co-(OEGMA)), was synthesised by copper-mediated controlled radical polymerisation (CRP) with increasing ratios of OEGMA : DEGMA. These polymers were combined in two ways to form nanoparticles with controllable thermal transition temperatures as measured by particle aggregation. The first technique involved the blending of two (PLA-b-P(DEGMA)-co-(OEGMA)) polymers together prior to assembling nanoparticles (NPs).

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2017

A hot melt 3D inkjet printing method with the potential to manufacture formulations in complex and adaptable geometries for the controlled loading and release of medicines is presented. This first use of a precisely controlled solvent free inkjet printing to produce drug loaded solid dosage forms is demonstrated using a naturally derived FDA approved material (beeswax) as the drug carrier and fenofibrate as the drug. Tablets with bespoke geometries (honeycomb architecture) were fabricated.

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2017

In patients with early-stage dementia and their caregiving partners, reciprocal dyadic coping (DC) is crucial for preventing or reducing depressive symptoms in both partners. This study examines the relationships between 'own DC' and 'perceived partner DC' with depressive symptoms in couples coping with dementia on individual (actor effects) and cross-person (partner effects) levels.
164 individuals (82 patients with early-stage dementia and their 82 caregiving partners; N= 82 dyads) participated in this prospective study with measures (DC, depressive symptoms, and dementia severity) taken at baseline and at six months.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2017

Chronic conditions are an increasing challenge for individuals and the health care system. Smartphones and health apps are potentially promising tools to change health-related behaviors and manage chronic conditions.
The aim of this study was to explore (1) the extent of smartphone and health app use, (2) sociodemographic, medical, and behavioral correlates of smartphone and health app use, and (3) associations of the use of apps and app characteristics with actual health behaviors.

View Full Text PDF Listings View primary source full text article PDFs.

Jan
2017

After weight loss, most individuals regain lost weight. Interventions to support the transition from successful loss to weight loss maintenance (WLM), regardless of the method of prior weight loss, are needed. The aims of this study were to (1) develop a face-to-face behavioural intervention session to support overweight and obese individuals who have recently lost a clinically significant amount of weight in the transition to WLM; (2) to assess the single-session intervention for acceptability and feasibility prior to its use in a larger, 12-month, multi-component trial; and (3) to optimise the intervention session for future use based on participant feedback.

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2017

there is limited data comparing conditions and health service use across care settings in centenarians. To improve health service delivery in centenarians, the aim of this study was to compare the proportion of centenarians who have chronic conditions, take medication and use health care services across different care settings.
this cohort study uses routine data from a major health insurance company serving Berlin, Germany and the surrounding region, containing almost complete information on health care transactions.

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2016

Fostering self-efficacy and planning in individuals can support the uptake and maintenance of regular physical activity. This study examined self-efficacy and planning as mechanisms of an online-delivered workplace health promotion intervention to enhance employees' physical activity. A special focus lay on reciprocal interrelations among self-efficacy and planning over time, as previous work predominantly accounted for only one predictive direction at a time.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
2016

The aim of this study was to develop and test the psychometric properties of a health knowledge test on common chronic conditions in the general population.
Operationalization based on a facet design led to 108 knowledge items on six conditions: cardiovascular disease, cancer, respiratory diseases, musculoskeletal system conditions, depression, and chronic pain. We refined the items (qualitative study 1; N=20) and selected the items by applying a mixed Rasch model (study 2; N=861).

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Given the well-established association between perceived stress and quality of life (QoL) in dementia patients and their partners, our goal was to identify whether relationship quality and dyadic coping would operate as mediators between perceived stress and QoL.
82 dyads of dementia patients and their spousal caregivers were included in a cross-sectional assessment from a prospective study. QoL was assessed with the Quality of Life in Alzheimer's Disease scale (QoL-AD) for dementia patients and the WHO Quality of Life-BREF for spousal caregivers.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2016

There are currently no instruments available to measure social cognitions towards food choice in children. This study aimed to test the feasibility and predictive validity of a novel measurement tool to assess food-related social cognitions. Sixty-eight children, five to eight years old, were asked to sort cards with photographs of four fruit and four sweet/savoury snacks as a mean to measure attitudes, subjective norms, perceived behavioural control (PBC), and intention.

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2016

The aim of this study was to investigate the effectiveness of a planning intervention (specifying when, where, and how to act) and an implementation intention intervention (specifying the same in the format of an if-then plan) in increasing self-reported brushing in adolescents.
The study adopted a cluster randomized controlled trial design, and 1158 students in 48 schools were randomized to planning, implementation intention, or active control conditions. After baseline assessment, all participants received a leaflet containing information and recommendations on oral health and instructions on correct brushing behavior.

View Full Text PDF Listings View primary source full text article PDFs.

Aug
2015

Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric mucosa using its outer membrane protein BabA. Structural information for BabA has been elusive, and thus, its molecular mechanism for recognizing Le(b) antigens remains unknown.

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2017

Precariousness, defined as low income combined with lack of security for retirement, can influence the way people grow old and result in health inequalities in old age.
A sequential mixed methods approach was used to identify differences in behavioral (physical activity), social (social network), and psychological resources (positive views on aging) that middle-aged individuals from both precarious and financially secure backgrounds use in preparation for positive aging and keep high levels of health and well-being. It was investigated whether positive views on aging can compensate the detrimental association of a lack of resources with health and well-being in midlife.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2017

We tested whether the relationship between subjective physical age and physical activity is mediated by planning. Participants came from a broad age range (25-78 years, M = 39.57, standard deviation = 10.

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2015

Although time-dependent treatment is available, most people delay contacting emergency medical services for stroke. Given differences in the healthcare system and public health campaigns, exploring between-country differences in stroke preparedness may identify novel ways to increase acute stroke treatment.
A survey was mailed to population-based samples in Ingham County, Michigan, US (n=2500), and Newcastle upon Tyne, UK (n=2500).

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

This study tested whether social cognitions from the reasoned action approach (RAA) can be reliably measured in a sample of primary school children (aged 4-6 years) and whether these RAA measures are predictive of physical activity.
Longitudinal observational study with repeated measures over six months.
RAA variables were measured using a novel choice paradigm between physically active and sedentary pastimes.

View Full Text PDF Listings View primary source full text article PDFs.

May
2015

to test the predictive utility of perceived barriers to objectively measured physical activity levels in a stratified sample of older adults when accounting for social-cognitive determinants proposed by the Theory of Planned Behaviour (TPB), and economic and demographic factors.
data were analysed from the Physical Activity Cohort Scotland survey, a representative and stratified (65-80 and 80+ years; deprived and affluent) sample of 584 community-dwelling older people, resident in Tayside, Scotland. Physical activity was measured objectively by accelerometry.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2015

Motivational interviewing (MI) has been shown to be an effective strategy for targeting obesity in adolescents, and parental involvement is associated with increased effectiveness. The aim of this study was to evaluate and compare the role of parental involvement in MI interventions for obese adolescents.
A total of 357 Iranian adolescents (aged 14-18 years) were randomized to receive an MI intervention or an MI intervention with parental involvement (MI + PI) or assessments only (passive control).

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2015

Physiologically relevant in vitro models can serve as biological analytical platforms for testing novel treatments and drug delivery systems. We describe the first steps in the development of a 3D human brain tumour co-culture model that includes the interplay between normal and tumour tissue along with nutrient gradients, cell-cell and cell-matrix interactions. The human medulloblastoma cell line UW228-3 and human foetal brain tissue were marked with two supravital fluorescent dyes (CDCFDASE, Celltrace Violet) and cultured together in ultra-low attachment 96-well plates to form reproducible single co-culture spheroids (d = 600 μm, CV% = 10%).

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2015

Helicobacter pylori is a pathogenic bacterium that has the remarkable ability to withstand the harsh conditions of the stomach for decades. This is achieved through unique evolutionary adaptations, which include binding Lewis(b) antigens found on the gastric epithelium using the outer membrane protein BabA. We show here the yield of a recombinant form of BabA, comprising its putative extracellular binding domain, can be significantly increased through the addition of a hexa-lysine tag to the C-terminus of the protein.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2014

Medication adherence rates after coronary artery bypass graft (CABG) surgery are low due to intentional (e.g., deliberately choosing not to take medication) and unintentional (e.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2015

Correlational evidence suggests that perceived control (PC) and intrinsic motivation (IM), key constructs in social cognitive and self-determination theories, may interact to reinforce behavior change.
This proof-of-principle study examines the independent and synergistic effects of interventions to increase PC and IM upon dental flossing frequency.
University students (n = 185) were randomized in a 2 × 2 full factorial design to receive two computer-based interventions: one to either increase or decrease PC and another to increase either IM or extrinsic motivation.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2015

The stroke awareness raising campaign 'Act FAST' (Face, Arms, Speech: Time to call Emergency Medical Services) has been rolled out in multiple waves in England, but impact on stroke recognition and response remains unclear.
The purpose of this study was to test whether providing knowledge of the FAST acronym through a standard Act FAST campaign leaflet increases accurate recognition and response in stroke-based scenario measures.
This is a population-based, cross-sectional survey of adults in Newcastle upon Tyne, UK, sampled using the electoral register, with individuals randomized to receive a questionnaire and Act FAST leaflet (n = 2500) or a questionnaire only (n = 2500) in 2012.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Three-dimensional cell culture has many advantages over monolayer cultures, and spheroids have been hailed as the best current representation of small avascular tumours in vitro. However their adoption in regular screening programs has been hindered by uneven culture growth, poor reproducibility and lack of high-throughput analysis methods for 3D. The objective of this study was to develop a method for a quick and reliable anticancer drug screen in 3D for tumour and human foetal brain tissue in order to investigate drug effectiveness and selective cytotoxic effects.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2014

The aim of this study was to investigate whether planning a dental appointment is a predictor of actual dental visits over a one-year period when controlling for past attendance, demographic factors, and dental health beliefs. In addition, the planning-attendance association was explored to determine whether dental anxiety and educational status moderated this relationship.
A total of N = 1,422 adults with a mean age of M = 44.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2013

Physical activity (PA) in older adults is influenced by a range of environmental, demographic, health-related, social, and psychological variables. Social cognitive psychological models assume that all influences on behaviour operate indirectly through the models constructs, i.e.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2014

The appropriateness of existing quality of life (QoL) instruments in small-scale, homelike care facilities for people with dementia is as yet unknown. This study evaluated the psychometric properties of three QoL instruments in German shared-housing arrangements (SHA).
A cross-sectional study was conducted in 36 SHA in Berlin to evaluate the acceptability, internal consistency, and validity (construct, convergent, and discriminant) of three QoL instruments: Alzheimer's Disease Related Quality of Life (ADRQL), Quality of Life-Alzheimer's Diseases (QoL-AD), and measuring QUAlity of LIfe in DEMentia (QUALIDEM).

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2014

A randomized controlled trial compared an age-tailored intervention to increase physical activity levels in older adults to an age-neutral intervention.
Both interventions communicated activity planning strategies and messages to improve self-efficacy. On top of this, the age-tailored intervention also included two lifespan components that targeted present orientation and emotional focus, and fostered strategies of selection, optimization, and compensation.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Applying the health action process approach (HAPA) to vaccination behaviour as a single-event health behaviour to study vaccination adherence and its predictors in a worksite flu vaccination programme.
A total of N = 823 employees participated in a longitudinal survey. Predictors (risk perception, self-efficacy, positive and negative outcome expectancies, intention and planning) were assessed at Time 1, and behaviour was assessed five months later at Time 2.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2012

Three different formulations comprising two drugs, felodipine and hydrochlorothiazide (HCT) and two polymers, poly(vinyl pyrolidone) (PVP) and poly(lactic-co-glycolic acid) (PLGA) were inkjet printed as micro-dot arrays and analysed on an individual micro-spot basis by time-of-flight secondary ion mass spectrometry (ToF-SIMS). For the HCT/PLGA formulation, the spots showed heterogeneity of the drug and other chemical constituents. To further investigate these heterogeneities, multivariate curve resolution was applied to the ToF-SIMS hyperspectral image datasets.

View Full Text PDF Listings View primary source full text article PDFs.

Jan
2012

As 95% of all prescriptions are for orally administered drugs, the issue of oral absorption is central to the development of pharmaceuticals. Oral absorption is limited by a high molecular weight (>500 Da), a high log P value (>2.0) and low gastrointestinal permeability.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2012

Limitations in perceived lifetime can undermine long-term goal striving. Planning is supposed to translate intentions into health behaviors and to operate as a compensatory strategy to overcome goal striving deficits associated with a limited time perspective.
Two longitudinal studies were conducted examining the compensatory role of planning: an online survey on fruit and vegetable consumption (N = 909; 16-78 years; follow-up at 4 months) and a questionnaire study on physical exercise in older adults (N = 289; 60-95 years, over a half-year period).

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

This study tests the effects of affective and health-related outcome expectancies on physical exercise, assuming stronger direct and indirect (via intention) effects from affective outcome expectancy to physical exercise than from health-related outcome expectancy to exercise. Physical exercise and social cognitive variables were assessed at baseline, and 6- and 12-month follow-up in 335 older adults (60-95 years of age). Applying structural equation modelling, there was a direct effect from affective, but not from health-related outcome expectancy on intentions and behaviour.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
2011

We demonstrate the viability of using an ink-jet printer to produce a formulation capable of controlling the release of a drug. This is shown for the drug felodipine, an antihypertensive, with polyvinyl pirrolidone (PVP) as an excipient. As felodipine is a poorly water soluble drug, its molecular dispersion in a soluble polymer (ie.

View Full Text PDF Listings View primary source full text article PDFs.

Aug
2012

Fruit and vegetable consumption represents a nutritional goal to prevent obesity and chronic illness. To change dietary behaviors, people must be motivated to do so, and they must translate their motivation into actual behavior. The present experiment aims at the psychological mechanisms that support such changes, with a particular focus on dietary self-efficacy and planning skills.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2011

Social integration and social support are expected to facilitate the adoption and maintenance of physical activity. In the context of a physical activity intervention, we distinguished three partner status groups, serving as an indicator of social integration. It was hypothesized that individuals whose partner also participated in the intervention, as opposed to individuals whose partners did not participate, or individuals without an intimate partner, would benefit more in terms of their physical activity.

View Full Text PDF Listings View primary source full text article PDFs.

Aug
2010

Selecting polymers for drug encapsulation in pharmaceutical formulations is usually made after extensive trial and error experiments. To speed up excipient choice procedures, we have explored coarse-grained computer simulations (dissipative particle dynamics (DPD) and coarse-grained molecular dynamics using the MARTINI force field) of polymer-drug interactions to study the encapsulation of prednisolone (log p = 1.6), paracetamol (log p = 0.

View Full Text PDF Listings View primary source full text article PDFs.

Back to top