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Author: Pepa Atanassova (16)


Dec
1969

Adipose tissue secretes a variety of adipokines involved in the regulation of energy metabolism and insulin resistance. Metabolic syndrome corresponds to a clinical condition in which white adipose tissue is characterized by an increased production and secretion of inflammatory molecules which may have local effects on adipose tissue physiology but also systemic effects on other organs. The aim of this study was to assess the expression of leptin, NGF and adiponectin in women with metabolic syndrome compared to healthy controls.

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Dec
1969

Impaired sensitivity to insulin (the so called insulin resistance, IR) occurs in a number of genetic and acquired conditions, including obesity, non-insulin dependent diabetes mellitus, polycystic ovary syndrome (PCOS) and metabolic syndrome (MS). In this review we discuss the correlation between IR, the adipose tissue hormones and appetite and body weight regulators. Leptin acts as a major adipostat: it suppresses food intake and activates catabolic pathways associated with increased energy production.

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Dec
1969

The AIM of the study was to compare the levels of certain adipose tissue hormones in women with the two main morphological types of obesity - android and gynoid obesity.
The study included 2 groups of age- and weight-matched women with android (n = 32) and gynoid (n = 27) type of obesity, and a group of age-matched healthy women (n = 24) with normal weight and body constitution. Leptin, resistin, tumour necrosis factor alpha (TNFalpha), neuropeptide Y (NPY), glucose and insulin were measured.

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Dec
1969

The aim of the present work was to study the morphological characteristics of neonatal adipose tissue using rats as an animal model. The results revealed that the subcutaneous adipose tissue of newborns consists of packets of unilocular adipose cells (one large lipid drop occupying the whole cell and pushing the cytoplasm and the nucleus to the cell periphery) and some multilocular fat cells (several lipid droplets of different size and an almost centrally located nucleus). All the adipocytes demonstrated positive immunohistochemical expression for leptin, whereas the multilocular adipose cells were positive for cyclin D1.

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Dec
2011

Recent studies indicate that pravastatin improves whereas other statins impair glucose homeostasis in humans, but the underlying mechanisms are not clear. We examined the effect of pravastatin and atorvastatin on insulin sensitivity in a rat model.
Pravastatin (40 mg/kg/day) or atorvastatin (20mg/kg/day) were administered for 3 weeks and insulin sensitivity was assessed by measuring fasting plasma insulin, HOMA-IR, non-esterified fatty acids (NEFA) and glycerol levels, as well as by the hyperinsulinemic euglycemic clamp.

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Dec
2011

The great many hormones released by the endocrine cells of the glands and lining epithelium of gastric mucosa determine its significance for the processes in the gastrointestinal tract. One of these hormones, serotonin, plays an important role in the regulation of the motility, secretion and sensation in the gastrointestinal tract. The aim of the present study was to conduct immunohistochemical and electron microscopic studies of serotonin-producing EC cell of gastric mucosa.

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Dec
2011

The gastrointestinal tract in the early prenatal development is an endoblastic mesenchyme-lined tube. The endoblast differentiates and gives origin to all epithelial structures (covering epithelium, glands). The mesenchyme develops into connective tissue, blood vessels, the smooth muscle cells of lamina muscularis mucosae and muscular tunic.

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Jan
2009

This clinical and experimental study compared adipose tissue transplant behavior after two different techniques of purifying: centrifugation at 3400 rpm for 3 min and serum lavage without centrifugation.
Clinical evaluation was performed under standardized conditions for lipofilling on a series of 51 female patients, intentionally selected to have similar characteristics and assigned to two groups based on the method of processing. Experimentally, a culture system in diffusion chambers with vitaline membranes was designed to mimic the behavior and to study the morphology of the adipose tissue used for autografting.

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Dec
1969

This study presents the results of a clinicomorphological study of autologous fat transplantation in the face region. The aim was to investigate and compare adipose tissue morphology after it was purified by two methods--centrifugation and serum lavage, and to find a correlation between the histological outcomes and the postoperative results.
The evaluation was performed on a series of 30 patients assigned into two groups of 15 patients.

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Dec
1969

Mitochondria are an active and continuous source of reactive oxygen species (ROS) during respiration. The ROS increased production during endurance training is a result of an augmented electron transport through the respiratory chains, making in this way the mitochondria a potential target for oxidative damage. The Bcl-2 protein family plays a central role in the transition of apoptotic signals towards the mitochondria in stress-induced apoptosis.

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Dec
1969

The aim of the present study was to investigate the formation of the basal lamina in adipose cells during human embryonal development using transmission electronmicroscopy and immunohistochemistry (reactions for collagen type IV and laminin).
Material (subcutaneous tissue from the gluteal region) was taken from human embryos aged 6 to 12 weeks of gestation. Part of the material was prepared for immunohistochemical investigation for collagen type IV and laminin by the peroxidase-antiperoxidase (PAP) method with universal PAP mouse kit (Dako Corporation, Santa Barbara, CA, USA) and primary antibodies--monoclonal mouse anti-human collagen type IV in dilution 1:100 and monoclonal mouse anti-human laminin in dilution 1:100 (Dako Corporation, Santa Barbara, CA, USA).

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Dec
1969

By using histochemical, enzymohistochemical and immunohistochemical methods the present study aims to find out specific morphological markers in the precursors of the white subcutaneous adipocytes of human and rat embryos, which could be used for identification and help in clarification of the origin of that cell type.
On cryostat sections of subcutaneous tissue from the thigh region of human embryos and hind limb of rat embryos histological hematoxylineosin staining, Sudan III-hematoxylin staining and enzyme-histochemical reactions for lipoprotein lipase are performed. On paraffin section of the same material immunohistochemical reaction for leptin is performed.

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Dec
1969

The purpose of the present study was to investigate the single and combined effects of submaximal training and anabolic androgenic steroids (AAS) treatment on the activity of 3beta hydroxysteroid dehydrogenase (3betaHSD) in rat Leydig cells (LC). Forty male Wistar rats were distributed into 4 groups. Half of them exercised on treadmill.

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Dec
1969

To study the effect of short-term and long-term treatment with retabolil, an androgenic anabolic steroid, on the activity of the enzymes ATP and LPL in rat cardiomyocytes and adipocytes.
Six male Wistar rats (mean weight 195-200 g.) were given retabolil 50 mg/kg once subcutaneously, another six were treated with retabolil at the same dose subcutaneously once a week for 6 weeks and another six were used as controls treating them with physiological saline in the same way.

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Dec
1969

In the present study we investigated the process of differentiation of rat subcutaneous white adipocytes in situ using electron microscopy.
Rat fetuses (Wistar rat) at 15 - 21 days of pregnancy were used. Sections of the subcutaneous tissue of a hind leg were prepared for examination with transmission electron microscopy by routine techniques.

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Dec
1969

The aim of the present study was to follow up the histochemical and enzyme-histochemical characteristics of differentiating white adipose cells of rat in situ.
Nine rat fetuses aged 15-21 day of gestation were used. Fragments from the subcutaneous tissue of lower limb were frozen at -18 degrees C.

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