Helping You Find Full Text Journal Articles

Search Results:

Author: Stefanie von Felten (27)


Dec
2017

Aggressive behavior and violence in psychiatric patients have often been quoted to justify more restrictive settings in psychiatric facilities. However, the effects of open vs. locked door policies on aggressive incidents remain unclear.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2017

Delirium is a neurobehavioural disturbance that frequently develops particularly in the intensive care unit (ICU) population. It was first described more than half a century ago, where it was already discovered as a state that might come along with serious complications such as prolonged ICU and hospital stay, reduced quality of life and increased mortality. However, in most cases, there is still lack of proof for causal relationship.

View Full Text PDF Listings View primary source full text article PDFs.

May
2017

Cardiac surgery is accompanied by oxidative stress and systemic inflammatory response, which may be associated with organ dysfunction and increased mortality. Selenium and selenoenzymes are important constituents of anti-oxidative defense. We hypothesized that high-dose sodium selenite supplementation can attenuate the postoperative inflammation and might, therefore, improve clinical outcome.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Randomized controlled trials have shown the efficacy of systemic treatments in moderate-to-severe psoriasis. Clinical outcomes in psoriasis patients under real-world conditions are less well understood.
This study compared Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI) improvement in all psoriasis patients registered in the Swiss Dermatology Network for Targeted Therapies.

View Full Text PDF Listings View primary source full text article PDFs.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2017

The British National Institute of Clinical Excellence (NICE) guidelines recommend to use drug-eluting stents (DES) instead of bare-metal stents (BMS) only in lesions >15 mm in length or in vessels <3 mm in diameter. We analyzed the impact of stent length and stent diameter on in-stent restenosis (ISR) in the BASKET-PROVE study population and evaluated the cost-effectiveness of DES compared to BMS.
The BASKET-PROVE trial compared DES vs BMS in large coronary arteries (≥3 mm).

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2016

Cabazitaxel significantly improves overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC) progressing during or after docetaxel, but is associated with a higher rate of grade ≥3 neutropenia compared with docetaxel. We thus examined the relationship between cabazitaxel-induced grade ≥3 neutropenia, baseline neutrophil-lymphocyte ratio (NLR) and treatment outcomes.
Data from the experimental arm of the TROPIC phase 3 trial which randomly assigned men with mCRPC to cabazitaxel or mitoxantrone every 3 weeks, both combined with daily prednisone, were analysed.

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2016

Acquisition of IDH1 or IDH2 mutation (IDHmut) is among the earliest genetic events that take place in the development of most low-grade glioma (LGG). IDHmut has been associated with longer overall patient survival. However, its impact on malignant transformation (MT) remains to be defined.

View Full Text PDF Listings View primary source full text article PDFs.

Jun
2016

Postpartum haemorrhage (PPH) represents a leading cause of maternal morbidity and mortality. Giving oxytocin after birth reduces the risk for PPH. It has never been tested whether different methods of oxytocin administration affect the maternal outcome.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2015

Tissue engineering is a popular topic in peripheral nerve repair. Combining a nerve conduit with supporting adipose-derived cells could offer an opportunity to prevent time-consuming Schwann cell culture or the use of an autograft with its donor site morbidity and eventually improve clinical outcome. The aim of this study was to provide a broad overview over promising transplantable cells under equal experimental conditions over a long-term period.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2014

In multiple sclerosis (MS), periaqueductal lesions (PAL) have been described histopathologically.
We sought to investigate the frequency and characteristics of PAL on magnetic resonance images (MRIs) in patients with MS or clinically isolated syndrome (CIS).
We analyzed proton density (PD)-weighted MRIs of 247 MS and 10 CIS patients.

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2014

The tradeoff between stent thrombosis (ST) and major bleeding (MB) of 12- versus 6-month dual antiplatelet therapy (DAPT) after coronary stent implantation has not been clearly defined.
Definite/probable ST and MB (TIMI major and Bleeding Academic Research Consortium (BARC) ≥ 3) were compared in 2 subsequent trials with similar inclusion criteria but different DAPT duration, that is, BASKET (6 months; n = 557) and BASKET-PROVE (12 months; n = 2,314), between months 0 to 6 (DAPT in both trials), 7 to 12 (DAPT in BASKET-PROVE only), and 13 to 24 (aspirin in both trials) using propensity score-adjusted, time-stratified Cox proportional hazard models.
Overall, event rates were low with fewer ST but similar MB in prolonged DAPT.

View Full Text PDF Listings View primary source full text article PDFs.

Jan
2015

Biodegradable-polymer drug-eluting stents (BP-DES) were developed to be as effective as second-generation durable-polymer drug-eluting stents (DP-DES) and as safe >1 year as bare-metal stents (BMS). Thus, very late stent thrombosis (VLST) attributable to durable polymers should no longer appear.
To address these early and late aspects, 2291 patients presenting with acute or stable coronary disease needing stents ≥3.

View Full Text PDF Listings View primary source full text article PDFs.

Feb
2015

Non-invasive monitoring of inflammatory bowel disease is an unmet clinical need as patients in clinical remission may have residual mucosal inflammation preceding clinical relapse.
We aimed to assess the value of fecal calprotectin and standardized clinical activity scoring to monitor disease activity in ulcerative colitis under medical treatment.
Forty-one patients with ulcerative colitis were included in a prospective observational study.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2014

The purpose of this study was to evaluate prevalence, progression, treatment, and outcome of silent coronary artery disease (CAD) in asymptomatic patients with diabetes (DM) at high coronary risk.
Despite the close association of diabetes and CAD, general CAD screening in asymptomatic patients with DM is discouraged even though outcome data in patients at high coronary risk are lacking.
Prospective multicenter outcome study-with a pilot randomized treatment substudy.

View Full Text PDF Listings View primary source full text article PDFs.

Oct
2014

Although radiofrequency (RF) and cryoballoon (CB) based technologies for pulmonary vein isolation (PVI) have both individually been demonstrated to be effective and safe for the treatment of paroxysmal AF, head-to-head comparisons are lacking. The purpose of this study was to compare the outcome of cryoballoon versus radiofrequency ablation in patients with paroxysmal atrial fibrillation undergoing pulmonary vein isolation.
Out of a prospective registry of 327 patients undergoing PVI, 208 patients (age 58±11 years, ejection fraction 59±6%, left atrial size 39±6 mm) with paroxysmal AF were identified.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2014

Cerebrospinal fluid leakage is an immanent risk of cranial surgery with dural opening. Recognizing the risk factors for this complication and improving the technique of dural closure may reduce the associated morbidity and its surgical burden. The aim of this paper was to investigate whether the addition of TachoSil on top of the dural suture reduces postoperative CSF leakage compared with dural suturing alone and to assess the frequency and risk factors for dural leakage and potentially related complications after elective craniotomy.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2013

Patients presenting to the emergency department (ED) currently face inacceptable delays in initial treatment, and long, costly hospital stays due to suboptimal initial triage and site-of-care decisions. Accurate ED triage should focus not only on initial treatment priority, but also on prediction of medical risk and nursing needs to improve site-of-care decisions and to simplify early discharge management. Different triage scores have been proposed, such as the Manchester triage system (MTS).

View Full Text PDF Listings View primary source full text article PDFs.

Apr
2013

Low-grade gliomas (LGGs) are rare brain neoplasms, with survival spanning up to a few decades. Thus, accurate evaluations on how biomarkers impact survival among patients with LGG require long-term studies on samples prospectively collected over a long period.
The 210 adult LGGs collected in our databank were screened for IDH1 and IDH2 mutations (IDHmut), MGMT gene promoter methylation (MGMTmet), 1p/19q loss of heterozygosity (1p19qloh), and nuclear TP53 immunopositivity (TP53pos).

View Full Text PDF Listings View primary source full text article PDFs.

Nov
2012

Recent biodiversity-ecosystem functioning experiments in temperate grasslands have shown that productivity positively correlates with plant species richness. Resource partitioning (in particular, nitrogen [N] partitioning) has been proposed as one possible mechanism to explain this pattern. There is evidence for interspecific differences in chemical form, soil depth, and timing of N uptake.

View Full Text PDF Listings View primary source full text article PDFs.

Dec
1969

Heinz Ellenberg's historically important work on changes in the abundances of a community of grass species growing along experimental gradients of water table depth has played an important role in helping to identify the hydrological niches of plant species in wet meadows. We present a previously unpublished complete version of Ellenberg's dataset from the 1950s together with the results of a series of modern statistical analyses testing for hypothesized overyielding of aboveground net primary production as a consequence of resource-based niche differentiation. Interactions of species with water table depth and soil type in the results of our analyses are qualitatively consistent with earlier interpretations of evidence for differences in the fundamental and realized niches of species.

View Full Text PDF Listings View primary source full text article PDFs.

Sep
2012

To compare surgical outcome and quality of life of robot-assisted laparoscopic hysterectomy with conventional laparoscopic hysterectomy.
For this controlled clinical trial, patients with benign indications for hysterectomy were randomized to receive either a robotic (robotic group) or conventional laparoscopic hysterectomy (conventional group). The primary end point was total operating time; secondary end points were perioperative outcome, blood loss, and the change in quality of life.

View Full Text PDF Listings View primary source full text article PDFs.

Jul
2012

Persistent black holes (PBH) are associated with axonal loss and disability progression in multiple sclerosis (MS). The objective of this work was to determine if BHT-3009, a DNA plasmid-encoding myelin basic protein (MBP), reduces the risk of new lesions becoming PBH, compared to placebo, and to test if pre-treatment serum anti-MBP antibody levels impact on the effect of BHT-3009 treatment. In this retrospective, blinded MRI study, we reviewed MRI scans of 155 MS patients from a double-blind, randomized, phase II trial with three treatment arms (placebo, 0.

View Full Text PDF Listings View primary source full text article PDFs.

Mar
2010

1. Factorial analysis of variance (anova) with unbalanced (non-orthogonal) data is a commonplace but controversial and poorly understood topic in applied statistics. 2.

View Full Text PDF Listings View primary source full text article PDFs.

May
2009

Partitioning of soil nitrogen (N) by niche separation among species may be an important mechanism explaining species coexistence and positive biodiversity-productivity relationships in terrestrial plant communities. However, there is little experimental evidence for such partitioning, in particular, as assessed across a gradient of species richness. In experimental communities of one, three, and six temperate grassland species in the field, we tested whether increasing species richness (1) decreases niche breadths of individual species, (2) decreases niche overlap among species, and (3) increases niche breadth of whole communities.

View Full Text PDF Listings View primary source full text article PDFs.

View Full Text PDF Listings View primary source full text article PDFs.

Back to top